Description

Benzyl 2-Fluoro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenylcarbamate is a high-purity, advanced pharmaceutical intermediate featuring a protected boronic ester functional group. This compound is critical for enabling efficient cross-coupling reactions, such as the Suzuki-Miyaura reaction, which are foundational to modern medicinal chemistry and drug discovery. It is primarily utilized by research institutions and pharmaceutical companies engaged in the synthesis of novel, complex small-molecule therapeutics, particularly in oncology and CNS drug development pipelines.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, especially those requiring fluorinated aromatic systems.
• Suzuki-Miyaura Cross-Coupling Reagent: The pinacol boronate ester moiety serves as a stable, reactive handle for forming carbon-carbon bonds with aryl halides, enabling the construction of complex biaryl structures.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to introduce fluorinated phenyl groups into molecular scaffolds.
• Protease Inhibitor Development: The carbamate-protected aniline structure suggests potential utility in the synthesis of protease inhibitors and other enzyme-targeted therapies.
• Chemical Biology Probes: Can be employed to create fluorescent or affinity-labeled probes for target identification and validation studies.
• Agrochemical Synthesis: Serves as a precursor in the development of advanced crop protection agents with fluorinated aromatic components.
• Material Science Precursor: Potential use in creating organic electronic materials and ligands for catalytic systems.

Basic Information

Product Name	Benzyl 2-Fluoro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenylcarbamate
CAS No.	1218791-14-0
Molecular Formula	C20H23BFNO4
Molecular Weight	371.21 g/mol
Synonyms	Benzyl N-[2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]carbamate; 2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl benzylcarbamate; Benzyl (2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)carbamate; 1218791-14-0; (2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl) carbamic acid benzyl ester; Benzyl 2-fluoro-4-(pinacolatoboron)phenylcarbamate
EINECS	Contact for details

Quality Control

Our Benzyl 2-Fluoro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenylcarbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under an inert atmosphere when appropriate for prolonged use. Keep the container tightly sealed in a dry environment to prevent moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Single Unknown Impurity (HPLC)	≤1.0%
Total Impurities (HPLC)	≤3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.