Description

2-(4-Fluoro-3-Nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane is a high-purity boronic ester derivative, a critical building block in modern synthetic organic chemistry. Its value lies in enabling efficient, selective cross-coupling reactions, particularly the Suzuki-Miyaura reaction, which is fundamental for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality intermediates for drug discovery and specialty chemical synthesis.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those containing fluorinated and nitrated aromatic systems.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides where the 4-fluoro-3-nitrophenyl moiety is required.
• Material Science Research: Serves as a building block for creating organic electronic materials, such as OLEDs and semiconductors, through polymerization or functionalization.
• Cross-Coupling Reactions: Primarily employed in palladium-catalyzed Suzuki-Miyaura couplings to form biaryl bonds, a cornerstone reaction in medicinal and process chemistry.
• Chemical Biology & Probe Development: Utilized in the synthesis of molecular probes and labeled compounds for diagnostic and research applications.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research institutions for bespoke synthesis projects requiring specific boronic ester functionalities.

Basic Information

Product Name	2-(4-Fluoro-3-Nitrophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	1218791-09-3
Molecular Formula	C12H15BFNO4
Molecular Weight	267.06 g/mol
Synonyms	4-Fluoro-3-nitrophenylboronic acid pinacol ester; (4-Fluoro-3-nitrophenyl)boronic acid pinacol ester; 2-(4-Fluoro-3-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4-Fluoro-3-nitrobenzeneboronic acid pinacol ester; Pinacol (4-Fluoro-3-nitrophenyl)boronate; 1218791-09-3; 4-Fluoro-3-nitrophenyl-Bpin; 3-Nitro-4-fluorophenylboronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 2-(4-Fluoro-3-Nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment supports applications in GMP and ISO-compliant environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when prolonged exposure is anticipated to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.