Description

1-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Cyclopropanecarboxylic Acid is a high-purity, advanced pharmaceutical intermediate featuring a cyclopropane carboxylic acid moiety linked to a pinacol boronate ester. This compound is a critical building block in modern organic synthesis, enabling efficient cross-coupling reactions for the construction of complex molecular architectures. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a key boronic ester reagent for the palladium-catalyzed formation of carbon-carbon bonds, essential for creating biaryl and heterobiaryl structures in drug discovery.
• Pharmaceutical Intermediate: Used in the synthesis of potential therapeutic compounds, including kinase inhibitors, antiviral agents, and other small molecule drugs.
• Agrochemical Research: Employed in the development of new herbicides, fungicides, and plant growth regulators that require the cyclopropane motif for biological activity.
• Material Science Precursor: Acts as a monomer or functionalization agent in the synthesis of organic electronic materials, such as polymers for OLEDs or OFETs.
• Chemical Biology Probes: Utilized to create tagged molecules for studying biological pathways and protein-ligand interactions.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing targeted compounds for clients.

Basic Information

Product Name	1-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Cyclopropanecarboxylic Acid
CAS No.	1218790-98-7
Molecular Formula	C₁₆H₂₁BO₄
Molecular Weight	288.15 g/mol
Synonyms	1-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]cyclopropanecarboxylic acid; 1-(4-(Pinacolatoboron)phenyl)cyclopropanecarboxylic acid; 1-(4-Bpin-phenyl)cyclopropanecarboxylic acid; Cyclopropanecarboxylic acid, 1-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-; 1-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)cyclopropanecarboxylic acid; B-[4-(1-Carboxycyclopropyl)phenyl]boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 1-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Cyclopropanecarboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.