Description

2-Ethoxy-5-(Trifluoromethyl)Pyridine-3-Boronic Acid is a high-value, multi-functional boronic acid derivative used as a key synthetic intermediate. Its core value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone of modern pharmaceutical and agrochemical synthesis. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those containing pyridine and trifluoromethyl motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides, leveraging the pyridine core for biological activity.
• Material Science Research: Serves as a precursor for creating functionalized organic molecules used in organic light-emitting diodes (OLEDs), liquid crystals, and conductive polymers.
• Chemical Biology & Proteomics: Employed in the development of molecular probes and inhibitors for studying enzyme function and protein-protein interactions.
• Cross-Coupling Reactions: Specifically designed as a premium reagent for palladium-catalyzed Suzuki-Miyaura couplings to form carbon-carbon bonds with high efficiency and selectivity.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific custom synthesis projects.

Basic Information

Product Name	2-Ethoxy-5-(Trifluoromethyl)Pyridine-3-Boronic Acid
CAS No.	1218790-66-9
Molecular Formula	C8H9BF3NO3
Molecular Weight	235.0 g/mol
Synonyms	[2-Ethoxy-5-(trifluoromethyl)pyridin-3-yl]boronic acid; 3-Borono-2-ethoxy-5-(trifluoromethyl)pyridine; 2-Ethoxy-5-trifluoromethylpyridine-3-boronic acid; 5-(Trifluoromethyl)-2-ethoxypyridine-3-boronic acid; 1218790-66-9; Boronic acid, B-[2-ethoxy-5-(trifluoromethyl)-3-pyridinyl]-; B-[2-Ethoxy-5-(trifluoromethyl)-3-pyridinyl]boronic acid
EINECS	Contact for details

Quality Control

Our 2-Ethoxy-5-(Trifluoromethyl)Pyridine-3-Boronic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure consistency and compliance with research and development standards. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay (NMR)	≥ 95.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.