Description

4-(Propargylaminocarbonyl)Phenylboronic Acid Pinacol Ester is a high-purity, synthetically valuable boronic ester derivative. This compound serves as a crucial building block in modern organic synthesis, particularly for cross-coupling reactions. It is primarily utilized by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular architectures.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for forming carbon-carbon bonds between aryl/heteroaryl halides and this boronic ester, enabling the synthesis of biaryl structures common in active pharmaceutical ingredients (APIs).
• Pharmaceutical Intermediate: Used in the research and development of novel drug candidates, especially in oncology, CNS, and anti-inflammatory therapeutic areas.
• Agrochemical Synthesis: Employed in creating advanced herbicides, fungicides, and insecticides that require specific biphenyl or functionalized aromatic components.
• Material Science & OLED Development: Acts as a precursor for organic electronic materials, including hole-transport layers and emissive materials in organic light-emitting diodes (OLEDs).
• Chemical Biology & Probe Development: The propargyl group allows for further functionalization via click chemistry (CuAAC), making it useful for creating molecular probes and bioconjugates.
• Library Synthesis for Drug Discovery: Facilitates the rapid parallel synthesis of diverse compound libraries for high-throughput screening in medicinal chemistry.

Basic Information

Product Name	4-(Propargylaminocarbonyl)Phenylboronic Acid Pinacol Ester
CAS No.	1218790-49-8
Molecular Formula	C₁₇H₂₀BNO₄
Molecular Weight	313.16 g/mol
Synonyms	4-(Prop-2-yn-1-ylcarbamoyl)phenylboronic acid pinacol ester; 4-(Propargylcarbamoyl)phenylboronic acid pinacol ester; [4-(Prop-2-yn-1-ylaminocarbonyl)phenyl]boronic acid pinacol ester; 4-(Prop-2-ynylaminocarbonyl)benzeneboronic acid pinacol ester; N-Propargyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide; B-[4-[(2-Propynylamino)carbonyl]phenyl]boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 4-(Propargylaminocarbonyl)Phenylboronic Acid Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for sensitive synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable to support our clients in regulated development pathways.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and prevent hydrolysis of the boronic ester.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.