Description

5-(1-Pyrrolidinylmethyl)Thiophene-2-Boronic Acid Pinacol Ester is a high-value, organoboron building block crucial for modern synthetic chemistry, particularly in cross-coupling reactions. Its core value lies in enabling the efficient and precise construction of complex molecular architectures, which is fundamental to pharmaceutical and advanced materials research. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating novel active ingredients and functional molecules. CAS No. 1218790-45-4.

Application

• Pharmaceutical Intermediate: A key reagent in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, especially those containing thiophene and pyrrolidine pharmacophores.
• Agrochemical Synthesis: Used in the research and development of new pesticides and herbicides, leveraging its ability to form carbon-carbon bonds under mild conditions.
• Material Science Research: Employed in the creation of organic electronic materials, such as conductive polymers and organic light-emitting diodes (OLEDs), where the thiophene unit is essential.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing specialized ligands used in homogeneous catalysis.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological processes and target identification.
• Custom Synthesis and Contract Manufacturing: A critical building block for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences market.

Basic Information

Item	Detail
Product Name	5-(1-Pyrrolidinylmethyl)Thiophene-2-Boronic Acid Pinacol Ester
CAS No.	1218790-45-4
Molecular Formula	C15H24BNO2S
Molecular Weight	293.24 g/mol
Synonyms	5-(Pyrrolidin-1-ylmethyl)thiophene-2-boronic acid pinacol ester; 2-(5-((Pyrrolidin-1-yl)methyl)thiophen-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; Thiophene-2-boronic acid, 5-[(1-pyrrolidinyl)methyl]-, 1,1-dimethylethyl ester; 5-(Pyrrolidin-1-ylmethyl)thiophene-2-ylboronic acid pinacol ester; Boronic ester derivative of thiophene
EINECS	Contact for details

Quality Control

Every batch of 5-(1-Pyrrolidinylmethyl)Thiophene-2-Boronic Acid Pinacol Ester undergoes rigorous analytical testing to ensure high purity and batch-to-batch consistency, critical for reproducible research and process scale-up. Our quality assurance protocols are designed to meet the stringent requirements of pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Recommended long-term storage at 2-8°C (refrigerated) for optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.