Description

5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2-(Trifluoromethyl)Pyridine is a high-value organoboron building block, specifically a pyridine-substituted pinacol boronic ester, essential for modern synthetic chemistry. Its core value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone method for constructing complex molecules with high fidelity. This compound is primarily needed by research scientists and process chemists in the pharmaceutical, agrochemical, and advanced materials industries for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs), particularly those containing trifluoromethylpyridine motifs, which are prevalent in drug discovery for their metabolic stability and lipophilicity.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the boronic ester group allows for the introduction of the pyridine core into complex heterocyclic systems.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as ligands for metal-organic frameworks (MOFs) or components for organic light-emitting diodes (OLEDs).
• Cross-Coupling Reactions: Specifically designed as a coupling partner in palladium-catalyzed Suzuki-Miyaura reactions to form biaryl and heteroaryl carbon-carbon bonds under mild conditions.
• Chemical Biology & Probe Development: Utilized in the synthesis of molecular probes and tags for studying biological systems, leveraging the bioisosteric properties of the trifluoromethyl group.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis organizations (CSOs) and CDMOs serving the life sciences sector.

Basic Information

Item	Details
Product Name	5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2-(Trifluoromethyl)Pyridine
CAS No.	1218790-39-6
Molecular Formula	C13H17BF3NO2
Molecular Weight	287.09 g/mol
Synonyms	2-(Trifluoromethyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(trifluoromethyl)pyridine; 2-Trifluoromethyl-5-pyridineboronic acid pinacol ester; 5-Pyridineboronic acid, 2-(trifluoromethyl)-, 1,1-dimethylethyl ester; (2-(Trifluoromethyl)pyridin-5-yl)boronic acid pinacol ester; 1218790-39-6; 2-CF3-5-PyridineBpin
EINECS	Contact for details

Quality Control

Our 5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2-(Trifluoromethyl)Pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.