Description

2-(4-Methoxy-2-Trifluoromethyl-Phenyl)-4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolane is a high-purity boronic ester derivative, a critical building block in modern synthetic organic chemistry. Its value lies in enabling efficient and selective cross-coupling reactions, such as the Suzuki-Miyaura reaction, which is fundamental for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality intermediates for drug discovery and specialty chemical synthesis.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing trifluoromethyl and methoxy aryl motifs for enhanced bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides where the specific substitution pattern contributes to product efficacy and environmental profile.
• Material Science Research: Serves as a monomer or building block for developing organic electronic materials, including OLEDs and semiconductors.
• Cross-Coupling Reactions: Primarily employed in palladium-catalyzed Suzuki-Miyaura couplings to form biaryl and heterobiaryl bonds, a cornerstone of modern C-C bond formation.
• Chemical Biology & Medicinal Chemistry: Utilized in the discovery and optimization of drug candidates through library synthesis and structure-activity relationship (SAR) studies.
• Ligand and Catalyst Development: Acts as a synthetic handle for constructing sophisticated ligands and organometallic catalysts.

Basic Information

Product Name	2-(4-Methoxy-2-Trifluoromethyl-Phenyl)-4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolane
CAS No.	1218790-37-4
Molecular Formula	C14H18BF3O3
Molecular Weight	302.10 g/mol
Synonyms	(4-Methoxy-2-(trifluoromethyl)phenyl)boronic acid pinacol ester; 2-(4-Methoxy-2-(trifluoromethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4-Methoxy-2-(trifluoromethyl)benzeneboronic acid pinacol ester; Pinacol [4-methoxy-2-(trifluoromethyl)phenyl]boronate; 2-(4-Methoxy-2-Trifluoromethylphenyl)-1,3,2-Dioxaborolane, 4,4,5,5-Tetramethyl-; CAS 1218790-37-4; 4-Methoxy-2-trifluoromethylphenylboronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 2-(4-Methoxy-2-Trifluoromethyl-Phenyl)-4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolane is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications requiring high standards, including cGMP for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when appropriate to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (GC)	≥98.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.