Description

2-(3-Bromo-5-Isopropoxyphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane CAS NO 1218790-34-1 is a high-purity boronic ester derivative, a crucial building block in modern synthetic organic chemistry. Its primary value lies in enabling efficient and selective cross-coupling reactions, such as the Suzuki-Miyaura reaction, which is fundamental for constructing complex molecular architectures. This advanced intermediate is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries who require reliable, high-quality precursors for drug discovery and specialty chemical synthesis.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly for constructing biaryl and heterobiaryl structures.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides that require specific phenyl-boronate motifs.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as those used in OLEDs and organic photovoltaics, due to its functionalized aromatic core.
• Cross-Coupling Reactions: Primarily employed in palladium-catalyzed Suzuki-Miyaura couplings to form carbon-carbon bonds with high efficiency and functional group tolerance.
• Ligand and Catalyst Development: Utilized in the preparation of specialized ligands and organometallic catalysts for asymmetric synthesis.
• Chemical Biology Probes: Acts as a versatile handle for bioconjugation and the synthesis of molecular probes for biological target identification.

Basic Information

Product Name	2-(3-Bromo-5-Isopropoxyphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	1218790-34-1
Molecular Formula	C15H22BBrO3
Molecular Weight	341.05 g/mol
Synonyms	3-Bromo-5-isopropoxyphenylboronic acid pinacol ester; (3-Bromo-5-isopropoxyphenyl)boronic acid pinacol ester; 2-(3-Bromo-5-(propan-2-yloxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 3-Bromo-5-isopropoxybenzeneboronic acid pinacol ester; Pinacol (3-bromo-5-isopropoxyphenyl)boronate; B-(3-Bromo-5-isopropoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Our 2-(3-Bromo-5-Isopropoxyphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR (1H, 13C, 11B), and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with the standards required for pharmaceutical R&D and commercial scale-up.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.