Description

1-Boc-7-Chloroindole-3-Boronic Acid, Pinacol Ester is a high-value, protected boronic ester derivative used as a key synthetic intermediate in advanced organic chemistry. This compound matters for its role in facilitating efficient cross-coupling reactions, particularly the Suzuki-Miyaura reaction, which is fundamental to constructing complex molecular architectures. It is primarily needed by pharmaceutical R&D teams, agrochemical manufacturers, and specialty chemical producers for the development of new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel drug candidates, especially those containing complex indole scaffolds.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronate reagent for forming carbon-carbon bonds under mild conditions, enabling the construction of biaryl and heterobiaryl systems.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides that require specific halogenated indole structures.
• Material Science: Employed in the creation of organic electronic materials, such as OLEDs and conductive polymers, where precise molecular structure is key.
• Chemical Biology & Proteomics: Utilized as a tool compound or linker in the synthesis of probes for studying biological processes and protein interactions.
• Custom Synthesis & Contract Manufacturing: A staple reagent for CROs and CDMOs offering bespoke synthesis services for clients in life sciences.

Basic Information

Product Name	1-Boc-7-Chloroindole-3-Boronic Acid, Pinacol Ester
CAS No.	1218790-31-8
Molecular Formula	C19H25BClNO4
Molecular Weight	377.67 g/mol
Synonyms	1-Boc-7-Chloroindole-3-boronic acid pinacol ester; 7-Chloro-1-[(tert-butoxy)carbonyl]-1H-indole-3-boronic acid pinacol ester; tert-Butyl 7-chloro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-1-carboxylate; 1-(tert-Butoxycarbonyl)-7-chloroindole-3-boronic acid pinacol ester; 7-Chloro-1-Boc-indole-3-boronic acid pinacol ester; 1-Boc-7-Cl-indole-3-Bpin; BOC-7-Cl-Indole-3-Bpin; 1-Boc-7-chloro-1H-indole-3-boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 1-Boc-7-Chloroindole-3-Boronic Acid, Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR (1H, 13C), and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment. We adhere to cGMP principles for pharmaceutical-grade intermediates, ensuring traceability and documentation for regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon or nitrogen) when possible to maintain stability. Keep the container tightly sealed in a desiccator after opening.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.