Description

2-(3,5-Dichloro-4-Isopropoxyphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-purity, advanced boronic ester building block essential for modern synthetic chemistry. Its value lies in enabling precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone of pharmaceutical and agrochemical R&D. This compound is primarily needed by researchers and process chemists in the pharmaceutical, agrochemical, and material science industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system and inflammatory diseases.
• Agrochemical Synthesis: Used in the development of novel herbicides and fungicides, leveraging its halogenated aromatic structure for bioactive molecule construction.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of organic electronic materials, such as polymers for OLEDs and OFETs.
• Cross-Coupling Reactions: The primary application is as a coupling partner in palladium-catalyzed Suzuki-Miyaura reactions to form biaryl and heterobiaryl linkages.
• Chemical Biology Probes: Utilized in medicinal chemistry for creating tool compounds and probes to study biological pathways and protein functions.
• Custom Synthesis & Contract Manufacturing: A critical raw material for CDMOs (Contract Development and Manufacturing Organizations) producing bespoke organic molecules for clients.

Basic Information

Product Name	2-(3,5-Dichloro-4-Isopropoxyphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	1218790-28-3
Molecular Formula	C15H21BCl2O3
Molecular Weight	331.04 g/mol
Synonyms	3,5-Dichloro-4-isopropoxyphenylboronic acid pinacol ester; (3,5-Dichloro-4-isopropoxyphenyl)boronic acid pinacol ester; 4,4,5,5-Tetramethyl-2-[3,5-dichloro-4-(propan-2-yloxy)phenyl]-1,3,2-dioxaborolane; 2-(3,5-Dichloro-4-isopropoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 1218790-28-3; PINACOL (3,5-DICHLORO-4-ISOPROPOXYPHENYL)BORONATE
EINECS	Contact for details

Quality Control

Our 2-(3,5-Dichloro-4-Isopropoxyphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment and are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (argon or nitrogen) when the container is opened for use to prevent decomposition. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay (NMR)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.