Description

1-Boc-6-Bromoindole-3-Boronic Acid, Pinacol Ester is a high-purity, advanced pharmaceutical intermediate and versatile building block for organic synthesis. This compound matters for its critical role in facilitating efficient cross-coupling reactions, enabling the rapid construction of complex indole-based molecular architectures. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for drug discovery and fine chemical manufacturing. CAS No. 1218790-27-2.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting neurological disorders and oncology.
• Suzuki-Miyaura Cross-Coupling: Serves as a crucial boronic ester component for palladium-catalyzed C-C bond formation to create complex biaryl and heterobiaryl structures.
• Indole Chemistry Research: Used in academic and industrial R&D for exploring new indole derivatives and their biological activities.
• Agrochemical Synthesis: Building block for developing new active ingredients in crop protection and pest management products.
• Material Science: Potential monomer or precursor for creating functional organic materials and polymers with specific electronic properties.
• Chemical Biology Probes: Used in the development of molecular probes and tools for studying biological pathways and protein interactions.

Basic Information

Product Name	1-Boc-6-Bromoindole-3-Boronic Acid, Pinacol Ester
CAS No.	1218790-27-2
Molecular Formula	C₁₉H₂₅BBrNO₄
Molecular Weight	422.12 g/mol
Synonyms	tert-Butyl 6-bromo-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-1-carboxylate; 1-Boc-6-Bromo-3-boronic acid pinacol ester indole; 6-Bromo-1-(tert-butoxycarbonyl)indole-3-boronic acid pinacol ester; 1-N-Boc-6-bromoindole-3-boronic acid pinacol ester; (1-(tert-Butoxycarbonyl)-6-bromo-1H-indol-3-yl)boronic acid pinacol ester; BOC-6-Bromoindole-3-Boronic Acid Pinacol Ester; 6-Bromo-1-Boc-indole-3-boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 1-Boc-6-Bromoindole-3-Boronic Acid, Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high chemical purity and structural integrity, meeting the stringent requirements for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its hygroscopic and moisture-sensitive nature. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.