Description

1-Boc-7-Methoxyindole-3-Boronic Acid, Pinacol Ester is a high-purity, advanced pharmaceutical intermediate and versatile building block for organic synthesis. This compound is specifically designed for use in Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex molecules. It is an essential reagent for medicinal chemists and process R&D teams in the pharmaceutical, agrochemical, and advanced materials sectors, enabling the efficient synthesis of novel indole-based scaffolds.

Application

• Pharmaceutical Intermediate: A key building block in the research and development of new active pharmaceutical ingredients (APIs), particularly for creating complex indole derivatives.
• Suzuki-Miyaura Cross-Coupling: Serves as a critical boron-containing partner for palladium-catalyzed carbon-carbon bond formation, enabling the synthesis of biaryl and heterobiaryl structures.
• Medicinal Chemistry & Drug Discovery: Used in library synthesis for high-throughput screening and structure-activity relationship (SAR) studies to identify new drug candidates.
• Agrochemical Research: Employed in the synthesis of novel herbicides, fungicides, and insecticides that utilize indole motifs.
• Material Science: A precursor for creating organic electronic materials, such as organic light-emitting diodes (OLEDs) and conductive polymers.
• Academic & Contract Research: A valuable reagent for universities and CROs (Contract Research Organizations) conducting cutting-edge synthetic chemistry research.

Basic Information

Product Name	1-Boc-7-Methoxyindole-3-Boronic Acid, Pinacol Ester
CAS No.	1218790-26-1
Molecular Formula	C20H28BNO5
Molecular Weight	373.25 g/mol
Synonyms	1-(tert-Butoxycarbonyl)-7-methoxy-1H-indole-3-boronic acid pinacol ester; 7-Methoxy-1-Boc-indole-3-boronic acid pinacol ester; tert-Butyl 7-methoxy-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-1-carboxylate; 1-Boc-7-methoxyindole-3-boronic acid pinacol ester; 1-Boc-7-MeO-indole-3-Bpin; Boronic acid, B-[1-[[(1,1-dimethylethoxy)carbonyl]-7-methoxy-1H-indol-3-yl]-, pinacol ester
EINECS	Contact for details

Quality Control

Our 1-Boc-7-Methoxyindole-3-Boronic Acid, Pinacol Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its moisture-sensitive and easily oxidized nature. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.