Description

1-Boc-6-Chloroindole-3-Boronic Acid, Pinacol Ester is a high-purity, advanced pharmaceutical intermediate and versatile building block for organic synthesis. This compound is critically important for facilitating efficient cross-coupling reactions, particularly in the construction of complex indole-based molecular architectures. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for the development of new active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders, oncology, and inflammation.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a crucial boronic ester reagent for forming carbon-carbon bonds to introduce the 6-chloroindole moiety into complex molecules.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides that utilize indole chemistry.
• Material Science & OLED Development: Employed in the synthesis of organic semiconductors and light-emitting materials for electronic devices.
• Academic & Contract Research: Essential for methodological studies in synthetic organic chemistry and for custom synthesis projects in CROs (Contract Research Organizations).
• Peptidomimetics & Bioconjugation: Facilitates the creation of indole-containing peptide analogs and tools for chemical biology.

Basic Information

Product Name	1-Boc-6-Chloroindole-3-Boronic Acid, Pinacol Ester
CAS No.	1218790-24-9
Molecular Formula	C19H25BClNO4
Molecular Weight	377.67 g/mol
Synonyms	1-(tert-Butoxycarbonyl)-6-chloro-1H-indole-3-boronic acid pinacol ester; 6-Chloro-1-Boc-indole-3-boronic acid pinacol ester; 1-Boc-6-chloroindole-3-boronate pinacol ester; tert-Butyl 6-chloro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-1-carboxylate; 6-Chloro-1-N-Boc-indole-3-boronic acid pinacol ester; BOC-6-Chloroindole-3-Boronic Acid Pinacol Ester; 1-Boc-6-Cl-indole-3-Bpin
EINECS	Contact for details

Quality Control

Our 1-Boc-6-Chloroindole-3-Boronic Acid, Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural integrity, meeting the stringent requirements for advanced synthetic intermediates. Certificates of Analysis (COA) with full characterization data are available upon request to support your regulatory and R&D documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label or COA. This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.