Description

Methyl 5-Fluoro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Picolinate is a high-value, multi-functional chemical building block that serves as a critical intermediate in modern synthetic chemistry. Its core value lies in the strategic combination of a picolinate ester and a protected boronic acid (pinacol boronate ester) group, enabling precise cross-coupling reactions. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries who are developing novel active ingredients, particularly for constructing complex heterocyclic scaffolds.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for the synthesis of novel drug candidates, especially fluorinated heterocycles targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in constructing advanced, fluorinated active ingredients for crop protection agents, leveraging the bioactivity-enhancing properties of the fluorine atom.
• Material Science Research: Serves as a monomer or functionalization agent in the development of organic electronic materials, such as OLEDs and organic semiconductors, where precise molecular architecture is required.
• Ligand and Catalyst Development: Employed in the synthesis of novel bidentate or tridentate ligands for transition metal catalysis, utilizing the nitrogen of the picolinate ring.
• Chemical Biology Probes: Acts as a versatile handle for bioconjugation and the creation of fluorophore-labeled or bioactive small-molecule probes for target identification and validation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds under cGMP or research-grade conditions.

Basic Information

Product Name	Methyl 5-Fluoro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Picolinate
CAS No.	1218790-18-1
Molecular Formula	C13H17BFNO4
Molecular Weight	281.09 g/mol
Synonyms	Methyl 5-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)picolinate; 5-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)picolinic acid methyl ester; Methyl 5-Fluoro-4-(pinacolatoboron)picolinate; 4-Borono-5-fluoropicolinic acid methyl ester, pinacol ester; 5-Fluoro-4-(pinacolato-κO,κO')boranyl-2-pyridinecarboxylic acid methyl ester; CAS 1218790-18-1; 1218790-18-1
EINECS	Contact for details

Quality Control

Our Methyl 5-Fluoro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Picolinate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and Mass Spectrometry, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) with detailed specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Standard Grade) ≥99.0% (High Purity Grade)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.