Description

3-Chloro-4-Fluoro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzonitrile is a high-purity, multi-functional boronic ester building block essential for modern synthetic chemistry. Its core value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone method for constructing complex carbon-carbon bonds. This compound is critically needed by research and development teams in the pharmaceutical, agrochemical, and advanced materials sectors for the synthesis of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs), especially in drug discovery for oncology, CNS, and anti-infective therapies.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides requiring specific halogenated aromatic structures.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as OLED (Organic Light-Emitting Diode) emitters and charge transport materials.
• Ligand and Catalyst Development: Employed in the synthesis of sophisticated ligands and organometallic catalysts for asymmetric synthesis.
• Chemical Biology Probes: Utilized to create labeled molecules and probes for studying biological pathways and target engagement.
• Polymer Chemistry: Acts as a monomer or cross-linking agent in the development of specialty polymers with tailored properties.

Basic Information

Item	Detail
Product Name	3-Chloro-4-Fluoro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzonitrile
CAS No.	1218790-15-8
Molecular Formula	C13H14BClFNO2
Molecular Weight	281.52 g/mol
Synonyms	3-Chloro-4-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile; 2-(2-Chloro-6-fluoro-3-cyanophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 3-Chloro-4-fluoro-5-(pinacolatoboryl)benzonitrile; 5-Cyano-2-chloro-3-fluorophenylboronic acid pinacol ester; (3-Chloro-4-fluoro-5-cyanophenyl)boronic acid pinacol ester; CAS 1218790-15-8; Boronic ester intermediate 1218790-15-8
EINECS	Contact for details

Quality Control

Every batch of 3-Chloro-4-Fluoro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzonitrile is manufactured under strict quality management systems. We guarantee high chemical purity and lot-to-lot consistency through rigorous analytical testing, including NMR, HPLC, and GC-MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to ensure compliance with your research and production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged storage or after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.