Description

trans-1,2-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)cyclohexane is a high-purity, bifunctional boronic ester derivative, serving as a critical building block in modern synthetic chemistry. Its primary value lies in enabling efficient cross-coupling reactions, particularly Suzuki-Miyaura couplings, to construct complex organic frameworks with high precision and yield. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality intermediates for drug discovery, catalyst development, and polymer synthesis.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs) and complex drug candidates via palladium-catalyzed cross-coupling reactions.
• Agrochemical Synthesis: Used in constructing novel herbicide and fungicide molecules that require specific stereochemistry and functional group integration.
• Material Science & Polymer Chemistry: Building block for creating novel organic electronic materials, liquid crystals, and specialty polymers with tailored properties.
• Chemical Research & Development: A versatile reagent in academic and industrial R&D labs for exploring new C-C bond formation methodologies and creating molecular libraries.
• Ligand & Catalyst Preparation: Serves as a precursor for synthesizing novel bidentate ligands and organometallic catalysts.
• Synthesis of Sterically Hindered Biaryls: Particularly effective for constructing challenging, spatially demanding biaryl structures due to its trans-cyclohexyl backbone.

Basic Information

Product Name	trans-1,2-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)cyclohexane
CAS No.	1218790-09-0
Molecular Formula	C20H38B2O4
Molecular Weight	364.14 g/mol
Synonyms	trans-Cyclohexane-1,2-diylbis(4,4,5,5-tetramethyl-1,3,2-dioxaborolane); trans-1,2-Cyclohexanediyldimethanol, cyclic borate (2:1); trans-1,2-Bis(pinacolboronato)cyclohexane; trans-1,2-Bis(pinacolatoboryl)cyclohexane; trans-1,2-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)cyclohexane; trans-Cyclohexane-1,2-diyl bis(boronic acid pinacol ester); (1R,2R)-1,2-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)cyclohexane (enantiomer); (1S,2S)-1,2-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)cyclohexane (enantiomer)
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Quality Control

Our trans-1,2-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)cyclohexane is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive synthetic applications. All material is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry guidelines for fine chemical production, and specifications can be aligned with customer-specific requirements for advanced research and cGMP applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and purity. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Purity (NMR)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.