Description

2-(4-(Benzyloxy)-2-(Trifluoromethyl)Phenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-value boronic ester derivative, a crucial intermediate in modern synthetic chemistry. Its core value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a powerful method for constructing complex biaryl structures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, where it serves as a key building block for active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing complex aromatic and heteroaromatic systems.
• Agrochemical Synthesis: Used to construct novel herbicide and fungicide candidates through palladium-catalyzed coupling reactions.
• Material Science Research: Serves as a building block for creating organic electronic materials, such as those used in OLEDs and organic photovoltaics.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands and organometallic catalysts for asymmetric synthesis.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and protein interactions.
• Custom Synthesis and R&D: A vital reagent for contract research organizations (CROs) and academic laboratories engaged in novel compound library development.

Basic Information

Product Name	2-(4-(Benzyloxy)-2-(Trifluoromethyl)Phenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	1218790-07-8
Molecular Formula	C20H22BF3O3
Molecular Weight	378.19 g/mol
Synonyms	4-(Benzyloxy)-2-(trifluoromethyl)phenylboronic acid pinacol ester; 2-[4-(Benzyloxy)-2-(trifluoromethyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; [4-(Benzyloxy)-2-(trifluoromethyl)phenyl]boronic acid pinacol ester; 4-(Benzyloxy)-2-(trifluoromethyl)benzeneboronic acid pinacol ester; 2-(4-(Benzyloxy)-2-(trifluoromethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; Pinacol [4-(benzyloxy)-2-(trifluoromethyl)phenyl]boronate
EINECS	Contact for details

Quality Control

Our 2-(4-(Benzyloxy)-2-(Trifluoromethyl)Phenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC, to ensure high purity and consistency suitable for demanding synthetic applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, it is recommended to handle the material under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to minimize exposure to ambient moisture. Recommended storage temperature: 2-8°C for extended stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.