Description

2-Chloro-6-(Trifluoromethyl)Pyridine-4-Boronic Acid Pinacol Ester is a high-value, organoboron building block essential for modern synthetic chemistry. Its core value lies in enabling efficient carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in pharmaceutical and agrochemical research. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for constructing complex heterocyclic scaffolds. The CAS number for this compound is 1218790-05-6.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs), particularly those containing complex pyridine and trifluoromethyl motifs.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides with enhanced efficacy and selectivity.
• Suzuki-Miyaura Cross-Coupling: Serves as a critical boronic ester reagent for palladium-catalyzed coupling reactions to form biaryl and heterobiaryl structures.
• Material Science Research: Employed in the creation of organic electronic materials, ligands for catalysis, and functional polymers.
• Chemical Biology & Medicinal Chemistry: Facilitates the rapid exploration of structure-activity relationships (SAR) in drug discovery programs.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis organizations (CSOs) producing specialized fine chemicals.

Basic Information

Product Name	2-Chloro-6-(Trifluoromethyl)Pyridine-4-Boronic Acid Pinacol Ester
CAS No.	1218790-05-6
Molecular Formula	C₁₃H₁₄BClF₃NO₂
Molecular Weight	321.51 g/mol
Synonyms	4,4,5,5-Tetramethyl-2-[2-chloro-6-(trifluoromethyl)pyridin-4-yl]-1,3,2-dioxaborolane; 2-Chloro-6-(trifluoromethyl)pyridine-4-boronic acid pinacol ester; 2-Chloro-6-(trifluoromethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; [2-Chloro-6-(trifluoromethyl)pyridin-4-yl]boronic acid pinacol ester; Pinacol [2-chloro-6-(trifluoromethyl)pyridin-4-yl]boronate; CAS 1218790-05-6; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-chloro-6-(trifluoromethyl)pyridine
EINECS	Contact for details

Quality Control

Our 2-Chloro-6-(Trifluoromethyl)Pyridine-4-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR (¹H, ¹³C, ¹⁹F, ¹¹B), and GC/MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with full analytical data are provided and available upon request, supporting compliance with cGMP and ICH Q7 guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed under an inert atmosphere (argon or nitrogen) after opening to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.