Description

2-Ethyl-4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Thiazole is a high-value, organoboron-containing heterocyclic building block essential for modern synthetic chemistry. This compound matters as a key Suzuki-Miyaura cross-coupling reagent, enabling the efficient and selective formation of carbon-carbon bonds to construct complex molecular architectures. It is critically needed by pharmaceutical R&D teams, agrochemical innovators, and advanced materials scientists for the synthesis of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A crucial building block for synthesizing novel drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors, antiviral agents, and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and development of next-generation pesticides, herbicides, and fungicides, where the thiazole and boronate ester functionalities impart specific biological activity.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as components for OLEDs (Organic Light-Emitting Diodes) and conductive polymers, due to its conjugated thiazole system.
• Chemical Biology & Probe Development: Employed in the synthesis of bioconjugates and molecular probes for studying biological processes and target engagement.
• Cross-Coupling Reactions: Primarily utilized in palladium-catalyzed Suzuki-Miyaura cross-coupling reactions to introduce the 2-ethyl-4-methylthiazole moiety into more complex molecules.
• Ligand and Catalyst Development: Acts as a starting material for synthesizing novel ligands and organometallic catalysts used in asymmetric synthesis.

Basic Information

Product Name	2-Ethyl-4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Thiazole
CAS No.	1218789-94-6
Molecular Formula	C₁₂H₂₀BNO₂S
Molecular Weight	253.17 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-ethyl-4-methylthiazole; 2-Ethyl-4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiazole; 2-Ethyl-4-methylthiazole-5-boronic acid pinacol ester; (2-Ethyl-4-methylthiazol-5-yl)boronic acid pinacol ester; Thiazole-5-boronic acid, 2-ethyl-4-methyl-, pinacol ester; 1218789-94-6; 2-Ethyl-4-methyl-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)thiazole
EINECS	Contact for details

Quality Control

Every batch of our 2-Ethyl-4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Thiazole undergoes rigorous analytical testing to ensure it meets the high-purity standards required for sensitive synthetic applications. Our quality assurance protocols include advanced chromatographic and spectroscopic methods to verify identity, potency, and impurity profiles. Certificates of Analysis (COA) documenting purity (typically ≥95% by HPLC or GC), identity confirmation, and residual solvent levels are provided with each shipment to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. This product is hygroscopic (moisture-sensitive) and easily oxidized; prolonged exposure to air, moisture, or elevated temperatures should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥95% (Typical range 95%-98%)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.