Description

2,2,2-Trifluoro-1-(4-(5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Yl)Piperazin-1-Yl)Eth96% is a high-purity, trifluoromethylated piperazine-pyridine boronic ester building block, essential for modern synthetic chemistry. This compound is valued for its role in facilitating Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex molecules. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Research: Used to construct novel pesticide and herbicide molecules by introducing the trifluoromethyl and heterocyclic motifs.
• Material Science: Serves as a precursor for advanced organic electronic materials and liquid crystals.
• Cross-Coupling Reactions: Specifically designed as a boron reagent in palladium-catalyzed Suzuki-Miyaura couplings with aryl/heteroaryl halides.
• Library Synthesis: Enables the rapid generation of diverse compound libraries for high-throughput screening in drug discovery.
• Chemical Biology Probes: Used to create tagged molecules for studying biological pathways and protein interactions.

Basic Information

Product Name	2,2,2-Trifluoro-1-(4-(5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Yl)Piperazin-1-Yl)Eth96%
CAS No.	1218789-87-7
Molecular Formula	C19H28BF3N3O2
Molecular Weight	398.25 g/mol
Synonyms	1-[4-[5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridyl]piperazin-1-yl]-2,2,2-trifluoroethanone; 2,2,2-Trifluoro-1-[4-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridyl]piperazin-1-yl]ethanone; 2,2,2-Trifluoro-1-(4-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)piperazin-1-yl)ethanone; 1-(4-(5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)piperazin-1-yl)-2,2,2-trifluoroethanone; Trifluoromethyl Pyridine Piperazine Boronic Ester; Pyridine-Boronate Building Block
EINECS	Contact for details

Quality Control

Every batch of this advanced intermediate is produced under strict quality control protocols to ensure consistency and reliability for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality systems support development under cGMP guidelines for pharmaceutical research use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon/nitrogen) for long-term storage to maintain stability and purity. Keep container tightly sealed in a desiccated environment.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 96.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.