Description

2-(3-Isopropoxy-5-Methylphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-purity boronic ester derivative, a critical building block in modern synthetic organic chemistry. Its primary value lies in enabling efficient and selective Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex biaryl and heterobiaryl structures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, where it is used to develop novel active ingredients and functional molecules. The CAS number for this compound is 1218789-75-3.

Application

This versatile boronic ester is a key intermediate in the synthesis of complex organic molecules. Its primary and related applications include:

• Pharmaceutical Intermediate: A crucial building block for synthesizing active pharmaceutical ingredients (APIs), particularly those containing substituted biphenyl or heteroaryl motifs.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides requiring specific aryl-aryl linkages.
• Material Science Research: Serves as a monomer or precursor in the development of organic electronic materials, such as those for OLEDs and organic photovoltaics.
• Ligand and Catalyst Development: Employed in the synthesis of sophisticated ligands for catalysis and molecular recognition applications.
• Chemical Biology Probes: Useful for creating tagged molecules and probes for studying biological processes.
• Academic & Industrial R&D: A standard reagent in laboratory-scale and pilot-scale Suzuki-Miyaura cross-coupling reactions for method development and compound library synthesis.

Basic Information

Product Name	2-(3-Isopropoxy-5-Methylphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	1218789-75-3
Molecular Formula	C16H25BO3
Molecular Weight	276.18 g/mol
Synonyms	3-Isopropoxy-5-methylbenzeneboronic acid pinacol ester; (3-Isopropoxy-5-methylphenyl)boronic acid pinacol ester; 5-Methyl-3-(propan-2-yloxy)phenylboronic acid pinacol ester; Pinacol (3-isopropoxy-5-methylphenyl)boronate; 1218789-75-3; Boronic acid, B-(3-isopropoxy-5-methylphenyl)-, 1,1,1,1-tetramethyl-1,3,2-benzodioxaborole
EINECS	Contact for details

Quality Control

Our production of 2-(3-Isopropoxy-5-Methylphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing batch-specific results are provided and available upon request. We support cGMP-compliant manufacturing for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5% w/w

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.