Description

Methyl 3-(Cyclopropylmethoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate is a high-value, multi-functional boronic ester derivative designed for advanced synthetic chemistry. This compound serves as a critical Suzuki-Miyaura cross-coupling building block, enabling the efficient construction of complex biaryl structures essential in modern research and development. It is primarily utilized by pharmaceutical, agrochemical, and advanced material scientists for the discovery and synthesis of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing complex biaryl motifs.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides requiring specific aromatic coupling reactions.
• Material Science Research: Employed in the creation of organic electronic materials, such as polymers for OLEDs and organic photovoltaics, via palladium-catalyzed coupling.
• Chemical Biology & Probe Development: Facilitates the synthesis of labeled compounds and molecular probes for biological target identification and mechanism studies.
• Academic & Contract Research: A versatile reagent for methodological development in organic synthesis and catalysis within university and CRO laboratories.
• Liquid Crystal & Advanced Polymer Synthesis: Used to introduce rigid, angled aromatic units into polymer backbones or mesogenic cores for specialty materials.

Basic Information

Product Name	Methyl 3-(Cyclopropylmethoxy)-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)benzoate
CAS No.	1218789-62-8
Molecular Formula	C18H25BO5
Molecular Weight	332.20 g/mol
Synonyms	3-(Cyclopropylmethoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid methyl ester; Methyl 3-(cyclopropylmethoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate; 3-Cyclopropylmethoxy-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzoic acid methyl ester; Benzoic acid, 3-(cyclopropylmethoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, methyl ester; Pinacol ester of Methyl 3-(Cyclopropylmethoxy)-5-boronobenzoate; Methyl 3-(Cyclopropylmethoxy)-5-boronobenzoate pinacol ester
EINECS	Contact for details

Quality Control

Our production of Methyl 3-(Cyclopropylmethoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate adheres to stringent quality management protocols to ensure batch-to-batch consistency and reliability for critical synthetic applications. Each lot undergoes comprehensive analytical characterization, including HPLC purity assay, NMR confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) documenting identity, purity, and all relevant specifications is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.