Description

Methyl 3-Ethoxy-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzoate is a high-value, advanced pharmaceutical intermediate and organic synthesis building block. Its core value lies in the versatile boronic ester functional group, which enables critical carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions. This compound is essential for research chemists and process development teams in the pharmaceutical, agrochemical, and materials science industries who require reliable, high-purity precursors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs), especially in oncology and central nervous system (CNS) drug discovery pipelines.
• Suzuki-Miyaura Cross-Coupling Reagent: Enables efficient palladium-catalyzed coupling with aryl/vinyl halides to create biaryl and conjugated systems prevalent in modern organic molecules.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides requiring specific aryl-ether-boronate motifs.
• Material Science & OLED Development: Serves as a precursor for creating organic electronic materials, including charge-transport layers and emissive materials in OLED displays.
• Ligand & Catalyst Development: Utilized in the synthesis of novel bidentate ligands and organometallic catalysts for asymmetric synthesis.
• Chemical Biology & Proteolysis Targeting Chimeras (PROTACs): A valuable linker or warhead component in the design of bifunctional molecules for targeted protein degradation.

Basic Information

Item	Detail
Product Name	Methyl 3-Ethoxy-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzoate
CAS No.	1218789-54-8
Molecular Formula	C16H23BO5
Molecular Weight	306.16 g/mol
Synonyms	3-Ethoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid methyl ester; Methyl 3-ethoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3-ethoxybenzoic Acid Methyl Ester; Methyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-ethoxybenzoate; 3-Ethoxy-5-(pinacolatoboryl)benzoic Acid Methyl Ester; Methyl 3-ethoxy-5-(pinacolatoboryl)benzoate; 1218789-54-8; Pinacol 3-Ethoxy-5-(methoxycarbonyl)phenylboronate
EINECS	Contact for details

Quality Control

Our Methyl 3-Ethoxy-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzoate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR (1H, 13C, 11B), and GC/MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged operations to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure (1H, 13C)
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.