Description

3-Bromo-5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenol is a high-purity arylboronic ester derivative widely employed as a key coupling partner in palladium-catalyzed cross-coupling reactions. Its structural design—featuring both a phenolic hydroxyl group and a robust boronic ester moiety—enables selective functionalization for complex molecule synthesis with excellent chemoselectivity and stability under standard Suzuki-Miyaura conditions. This compound is essential for pharmaceutical R&D, agrochemical innovation, and advanced materials development where precise heteroaryl substitution is required.

Application

• Pharmaceutical intermediate for synthesizing kinase inhibitors and CNS-active compounds
• Building block in Suzuki-Miyaura cross-coupling to construct biaryl motifs in drug candidates
• Key reagent in the preparation of boron-containing PET tracers and radiopharmaceuticals
• Monomer for conjugated polymers and organic semiconductors used in OLED and OPV devices
• Intermediate in agrochemical synthesis, particularly for fungicidal and herbicidal analogues
• Substrate for sequential C–O/C–B functionalization in late-stage diversification strategies
• Tool compound in chemical biology for site-selective protein labeling via boronate affinity
• Research material for developing novel boron neutron capture therapy (BNCT) agents

Basic Information

Product Name	3-Bromo-5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenol
CAS No.	1218789-50-4
Molecular Formula	C12H16BBrO3
Molecular Weight	315.97 g/mol
Synonyms	3-Bromo-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol; 3-Bromo-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenol; 2-(3-Bromo-5-hydroxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 3-Bromo-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol; BORONIC ESTER PHENOL DERIVATIVE; CAS# 1218789-50-4; TMDP-Br-OH; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-bromophenol; 2-(3-Bromo-5-hydroxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborole
EINECS	Not listed

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch is verified for identity, assay, residual solvents, heavy metals, and trace impurities using validated HPLC, GC, NMR, and ICP-MS methods. Certificates of Analysis (COA) are available upon request and include full chromatographic traces, spectral data, and conformance to ACS, EP, and USP general chapters where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store at 15–25°C in a dry, well-ventilated area. Due to its hygroscopic nature, minimize exposure to ambient moisture by using desiccant-equipped storage and maintaining nitrogen purge during handling.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Assay (HPLC)	≥ 98.5%
Identification (IR)	Conforms to reference standard
Identification (NMR)	Conforms to reference standard
Residual Solvents (GC)	Meets ICH Q3C Class 3 limits
Water (Karl Fischer)	≤ 0.5%
Heavy Metals (as Pb)	≤ 10 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.