Description

2-(3-Bromo-5-Isobutoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane is a high-purity boronic ester derivative, a critical building block in modern synthetic organic chemistry. Its value lies in enabling efficient, selective carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone of pharmaceutical and advanced materials development. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and OLED materials industries who require reliable, high-quality intermediates for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly for constructing biaryl and heterobiaryl scaffolds.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides requiring specific phenyl-boronate coupling partners.
• Material Science: Serves as a monomer or building block for creating advanced polymers, liquid crystals, and organic electronic materials for OLEDs and semiconductors.
• Chemical Research: A versatile reagent in academic and industrial R&D labs for methodology development and the synthesis of complex organic molecules.
• Cross-Coupling Reactions: Primarily employed in palladium-catalyzed Suzuki-Miyaura cross-coupling to introduce the 3-bromo-5-isobutoxyphenyl moiety into target molecules.

Basic Information

Product Name	2-(3-Bromo-5-Isobutoxyphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	1218789-48-0
Molecular Formula	C16H24BBrO3
Molecular Weight	355.08 g/mol
Synonyms	3-Bromo-5-isobutoxyphenylboronic acid pinacol ester; (3-Bromo-5-isobutoxyphenyl)boronic acid pinacol ester; 2-(3-Bromo-5-isobutoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 3-Bromo-5-isobutoxybenzeneboronic acid pinacol ester; Pinacol (3-bromo-5-isobutoxyphenyl)boronate; B-(3-Bromo-5-isobutoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Our 2-(3-Bromo-5-Isobutoxyphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for demanding synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality systems support compliance with global regulatory standards for advanced chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to maintain optimal quality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.