Description

Ethyl 2-(3-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)acetate is a high-purity, synthetically valuable boronic ester derivative. This compound serves as a crucial advanced pharmaceutical intermediate and building block in modern organic synthesis, particularly for Suzuki-Miyaura cross-coupling reactions. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors to construct complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, especially those containing biaryl motifs.
• Suzuki-Miyaura Cross-Coupling Reagent: Enables the formation of carbon-carbon bonds between aryl/heteroaryl halides and this boronate ester under palladium catalysis.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides requiring specific chlorinated phenoxy structures.
• Liquid Crystal & OLED Material Precursor: Serves as a monomer or intermediate in the synthesis of advanced organic electronic materials.
• Polymer Chemistry: Incorporation into specialty polymers to impart specific thermal, optical, or mechanical properties.
• Chemical Research & Development: A versatile reagent for exploring new synthetic methodologies and constructing complex organic molecules in academic and industrial labs.

Basic Information

Item	Details
Product Name	Ethyl 2-(3-Chloro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)phenoxy)acetate
CAS No.	1218789-47-9
Molecular Formula	C18H26BClO5
Molecular Weight	368.66 g/mol
Synonyms	3-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxyacetic acid ethyl ester; Ethyl (3-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)acetate; 2-(3-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)acetic acid ethyl ester; 3-Chloro-5-(pinacolatoboryl)phenoxyacetic acid ethyl ester; Pinacol [3-chloro-5-(ethoxycarbonylmethoxy)phenyl]boronate; CAS 1218789-47-9; Boronic acid, B-[3-chloro-5-[(ethoxycarbonyl)methoxy]phenyl]-, pinacol ester
EINECS	Contact for details

Quality Control

Our Ethyl 2-(3-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)acetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC, to ensure identity, purity, and consistency. Certificates of Analysis (COA) documenting full specifications are provided with every shipment. We support compliance with cGMP, ICH Q7, and other relevant pharmaceutical guidelines for intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged storage or after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.