Description

2-(3-Butoxy-5-Chlorophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-purity, advanced pharmaceutical intermediate and versatile building block in organic synthesis. This compound matters for its critical role in facilitating Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex biaryl structures. It is primarily needed by R&D chemists and process development teams in the pharmaceutical, agrochemical, and advanced materials industries seeking reliable, high-quality boron reagents for drug discovery and fine chemical manufacturing. CAS No. 1218789-45-7.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing complex aryl-aryl bonds.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides that require specific chlorinated biaryl motifs.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as those used in OLEDs and organic photovoltaics, due to its functionalized aromatic core.
• Cross-Coupling Reactions: An essential reagent in palladium-catalyzed Suzuki-Miyaura cross-coupling for the efficient formation of carbon-carbon bonds under mild conditions.
• Chemical Library Development: Employed in combinatorial chemistry and high-throughput screening to generate diverse compound libraries for biological testing.
• Ligand and Catalyst Preparation: Useful in the synthesis of specialized ligands and organometallic catalysts used in asymmetric synthesis.

Basic Information

Item	Detail
Product Name	2-(3-Butoxy-5-Chlorophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	1218789-45-7
Molecular Formula	C16H24BClO3
Molecular Weight	310.62 g/mol
Synonyms	3-Butoxy-5-chlorophenylboronic acid pinacol ester; (3-Butoxy-5-chlorophenyl)boronic acid pinacol ester; 5-Chloro-3-butoxyphenylboronic acid pinacol ester; 2-(5-Chloro-3-butoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 3-Chloro-5-butoxyphenylboronic acid pinacol ester; B-(3-Butoxy-5-chlorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Every batch of 2-(3-Butoxy-5-Chlorophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for advanced synthetic applications. Our quality assurance protocols are designed to support cGMP and ISO standards where applicable. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.