Description

2-(3-Chloro-5-Isopropoxyphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane CAS NO 1218789-42-4 is a high-purity boronic ester derivative, a crucial advanced pharmaceutical intermediate and Suzuki-Miyaura cross-coupling reagent. Its value lies in enabling the efficient synthesis of complex biaryl structures, which are foundational to many modern active pharmaceutical ingredients (APIs) and agrochemicals. This compound is essential for R&D and production teams in the pharmaceutical, agrochemical, and material science industries seeking to develop new small molecule therapeutics and functional materials.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly in oncology and CNS therapeutic areas.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a stable, air-tolerant organoboron reagent for forming carbon-carbon bonds between aryl groups under mild conditions.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides with complex aromatic backbones.
• Material Science Research: Employed in the creation of organic electronic materials, such as OLEDs and organic photovoltaics, where precise molecular architecture is required.
• Ligand and Catalyst Development: Acts as a precursor for synthesizing specialized ligands used in homogeneous catalysis.
• Chemical Biology Probes: Utilized to create tagged molecules for studying biological pathways and protein interactions.

Basic Information

Product Name	2-(3-Chloro-5-Isopropoxyphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	1218789-42-4
Molecular Formula	C15H22BClO3
Molecular Weight	296.60 g/mol
Synonyms	3-Chloro-5-isopropoxyphenylboronic acid pinacol ester; (3-Chloro-5-isopropoxyphenyl)boronic acid pinacol ester; 2-(3-Chloro-5-(propan-2-yloxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 3-Chloro-5-isopropoxybenzeneboronic acid pinacol ester; Pinacol (3-chloro-5-isopropoxyphenyl)boronate; Boronic acid, B-(3-chloro-5-isopropoxyphenyl)-, 1,1-dimethylethyl ester; CAS 1218789-42-4
EINECS	Contact for details

Quality Control

Every batch of our 2-(3-Chloro-5-Isopropoxyphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is manufactured under strict quality management systems. We guarantee high purity and lot-to-lot consistency through rigorous analytical testing, including HPLC, NMR, and GC-MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to ensure it meets your specific research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.