Description

2-(3-Chloro-5-Propoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane is a high-purity, advanced boronic ester building block essential for modern synthetic chemistry. This compound matters because it serves as a critical intermediate in cross-coupling reactions, enabling the efficient construction of complex molecules for research and development. Pharmaceutical, agrochemical, and advanced material scientists need this reagent for creating novel active ingredients and functional polymers. Its defined structure and reactivity profile make it a valuable asset for streamlining synthetic routes and accelerating discovery timelines.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly in medicinal chemistry programs targeting CNS and inflammatory diseases.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and fungicides, where the chloropropoxyphenyl moiety contributes to biological activity.
• Organic Light-Emitting Diodes (OLEDs): Serves as a building block for electron-transport materials and host molecules in the fabrication of high-efficiency display and lighting technologies.
• Liquid Crystal & Polymer Chemistry: Incorporated into the synthesis of advanced monomers for specialty polymers and liquid crystal materials with tailored electronic and optical properties.
• Material Science Research: Employed in creating novel organic frameworks (MOFs/COFs) and functionalized surfaces for catalysis, sensing, and separation applications.
• Chemical Biology & Bioconjugation: Utilized as a handle for site-specific labeling and modification of biomolecules due to the selective reactivity of the boronic ester group.

Basic Information

Product Name	2-(3-Chloro-5-Propoxyphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	1218789-41-3
Molecular Formula	C15H22BClO3
Molecular Weight	296.59 g/mol
Synonyms	3-Chloro-5-propoxybenzeneboronic acid pinacol ester; (3-Chloro-5-propoxy)phenylboronic acid pinacol ester; 3-Chloro-5-propoxybenzeneboronic acid, pinacol ester; Pinacol (3-chloro-5-propoxyphenyl)boronate; 2-(3-Chloro-5-propoxy)phenyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 3-Chloro-5-propoxy phenylboronic acid pinacol ester; 3-Chloro-5-propoxybenzeneboronic acid, 1,3,2-dioxaborolane deriv.
EINECS	Contact for details

Quality Control

Our 2-(3-Chloro-5-Propoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive applications. Each lot undergoes rigorous analytical testing, including HPLC, NMR (1H, 13C, 11B), and GC-MS, to confirm identity, potency, and impurity profiles. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.