Description

2-(3-Chloro-5-Ethoxyphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-purity boronic ester derivative, a crucial building block in modern synthetic organic chemistry. Its primary value lies in its role as a key intermediate in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl structures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality intermediates for drug discovery and specialty chemical synthesis.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing complex biaryl or heterobiaryl motifs.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides where specific phenyl ring substitutions are required.
• Material Science: Serves as a building block for creating organic electronic materials, such as those used in OLEDs (Organic Light-Emitting Diodes) and semiconductors.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands and organometallic catalysts for asymmetric synthesis and other advanced catalytic processes.
• Chemical Research: A versatile reagent in academic and industrial R&D labs for exploring new carbon-carbon bond-forming methodologies and constructing molecular libraries.
• Fine Chemical Production: Integral to the custom synthesis of complex, high-value specialty chemicals for various industrial applications.

Basic Information

Product Name	2-(3-Chloro-5-Ethoxyphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	1218789-40-2
Molecular Formula	C14H20BClO3
Molecular Weight	282.57 g/mol
Synonyms	3-Chloro-5-ethoxybenzeneboronic acid pinacol ester; (3-Chloro-5-ethoxyphenyl)boronic acid pinacol ester; 3-Chloro-5-ethoxyphenylboronic acid pinacol ester; 2-(3-Chloro-5-ethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 1,3,2-Dioxaborolane, 2-(3-chloro-5-ethoxyphenyl)-4,4,5,5-tetramethyl-; Pinacol (3-chloro-5-ethoxyphenyl)boronate; 3-Chloro-5-ethoxybenzeneboronic acid, pinacol ester
EINECS	Contact for details

Quality Control

Every batch of 2-(3-Chloro-5-Ethoxyphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the high standards required for sensitive applications like pharmaceutical R&D. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for all shipments. Our quality protocols are designed to ensure batch-to-batch consistency and reliability for your critical synthetic processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area. The product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and purity. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.