Description

4-(1-Aminocyclopropyl)Phenylboronic Acid, Pinacol Ester is a high-value, multifunctional boronic ester building block designed for advanced organic synthesis. This compound is particularly significant for its dual functionality, combining a protected boronic acid group with a primary amine, enabling sequential cross-coupling and amide bond formation in complex molecule assembly. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and chemical probes.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for constructing biaryl scaffolds found in drug candidates.
• Proteolysis-Targeting Chimera (PROTAC) Development: Used to synthesize bifunctional linkers that connect target protein binders to E3 ligase ligands.
• Agrochemical Synthesis: Employed in creating novel herbicides and fungicides with complex aromatic structures.
• Material Science Research: Serves as a monomer or functionalization agent in the development of advanced polymers and organic electronic materials.
• Chemical Biology Tool: Utilized for labeling and modifying biomolecules via its reactive amine and boronate groups.
• Library Synthesis for High-Throughput Screening: Enables rapid diversification to create focused compound libraries for biological activity screening.

Basic Information

Item	Details
Product Name	4-(1-Aminocyclopropyl)Phenylboronic Acid, Pinacol Ester
CAS No.	1218789-38-8
Molecular Formula	C15H22BNO2
Molecular Weight	259.15 g/mol
Synonyms	4-(1-Aminocyclopropyl)benzeneboronic acid pinacol ester; 1-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]cyclopropanamine; 4-(Aminocyclopropyl)phenylboronic acid pinacol ester; B-[4-(1-Aminocyclopropyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; (4-(1-Aminocyclopropyl)phenyl)boronic acid pinacol ester; 4-(1-Azanylcyclopropyl)phenylboronic acid pinacol ester
EINECS	Contact for details

Quality Control

Every batch of 4-(1-Aminocyclopropyl)Phenylboronic Acid, Pinacol Ester is produced and tested under a strict quality management system. We guarantee high chemical purity and lot-to-lot consistency through comprehensive analytical techniques including HPLC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) providing identity, purity, and impurity profiles is supplied with each shipment to ensure compliance with your research and development protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its hygroscopic and moisture-sensitive nature. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.