Description

Cyclopropyl-[5-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Pyrimidin-2-Yl]-Amine is a high-value boronic ester-protected pyrimidine derivative, serving as a critical building block in modern synthetic chemistry. Its core value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors, where it is used to introduce the cyclopropylaminopyrimidine pharmacophore into target molecules.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Research: Building block for developing novel fungicides, herbicides, and insecticides with the cyclopropyl-pyrimidine motif.
• Material Science: Used in the creation of organic electronic materials, such as ligands for OLEDs or molecular sensors.
• Chemical Biology & Proteomics: Employed in the design and synthesis of chemical probes and molecular tools for target identification and validation.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.
• Academic & Discovery Chemistry: Facilitates rapid analog synthesis and structure-activity relationship (SAR) studies in medicinal chemistry programs.

Basic Information

Product Name	Cyclopropyl-[5-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Pyrimidin-2-Yl]-Amine
CAS No.	1218789-33-3
Molecular Formula	C₁₃H₂₀BN₃O₂
Molecular Weight	261.13 g/mol
Synonyms	2-Pyrimidinamine, 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-N-cyclopropyl-; N-Cyclopropyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-amine; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-N-cyclopropylpyrimidin-2-amine; Cyclopropyl-[5-(tetramethyl-1,3,2-dioxaborolan-2-yl)-pyrimidin-2-yl]-amine; Boronic acid, B-[2-(cyclopropylamino)-5-pyrimidinyl]-, 1,1-dimethylethyl ester; 1218789-33-3
EINECS	Contact for details

Quality Control

Our Cyclopropyl-[5-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Pyrimidin-2-Yl]-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high purity and consistent performance for sensitive cross-coupling applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Recommended storage temperature: 2-8°C for extended stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.