Description

5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-n-(2,2,2-Trifluoroethyl)Pyrimidin-2-Amine is a high-value, organoboron building block essential for modern synthetic chemistry, particularly in pharmaceutical research and development. Its core value lies in the pinacol boronate ester functional group, which enables efficient Suzuki-Miyaura cross-coupling reactions for constructing complex molecular architectures. This compound is primarily needed by R&D chemists and process scientists in the pharmaceutical, agrochemical, and advanced materials sectors for creating novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, especially those containing pyrimidine and trifluoroethyl motifs.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a critical boron reagent for forming carbon-carbon bonds between the pyrimidine ring and various aryl or heteroaryl halides.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides that require specific heterocyclic frameworks.
• Material Science: Potential precursor for creating organic electronic materials, such as those used in OLEDs or semiconductors, due to its conjugated system.
• Chemical Biology & Probe Development: Utilized in the synthesis of molecular probes and labeled compounds for biochemical assays and diagnostic applications.
• Library Synthesis for Drug Discovery: Enables the rapid, parallel synthesis of diverse compound libraries for high-throughput screening in medicinal chemistry.

Basic Information

Item	Details
Product Name	5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-n-(2,2,2-Trifluoroethyl)Pyrimidin-2-Amine
CAS No.	1218789-32-2
Molecular Formula	C12H19BF3N3O2
Molecular Weight	305.11 g/mol
Synonyms	2-Amino-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-N-(2,2,2-trifluoroethyl)pyrimidine; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-N-(2,2,2-trifluoroethyl)-2-pyrimidinamine; N-(2,2,2-Trifluoroethyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-amine; 5-Pinacolatoboryl-N-(2,2,2-trifluoroethyl)pyrimidin-2-amine; 5-BPin-N-(2,2,2-trifluoroethyl)pyrimidin-2-amine (abbrev.); CAS 1218789-32-2
EINECS	Contact for details

Quality Control

Our 5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-n-(2,2,2-Trifluoroethyl)Pyrimidin-2-Amine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP standards for use in regulated research environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.