Description

Methyl (2S,4S)-4-[2-(Trifluoromethyl)Phenoxy]-2-Pyrrolidinecarboxylate is a high-purity, chiral pyrrolidine derivative of significant interest in advanced organic synthesis. This compound matters as a sophisticated building block for the development of novel active pharmaceutical ingredients (APIs) and fine chemicals, where its defined stereochemistry and trifluoromethylphenoxy moiety are critical for imparting specific biological activity and metabolic stability. Pharmaceutical researchers and process chemists in the life sciences industry need this intermediate for constructing complex molecular architectures in drug discovery and development programs.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of potential drug candidates, particularly in central nervous system (CNS) and antiviral research.
• Asymmetric Catalysis: Serves as a precursor for chiral ligands or organocatalysts used in stereoselective synthesis.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore the impact of the trifluoromethylphenoxy group on potency and selectivity.
• Fine Chemical Synthesis: Employed in the multi-step production of complex agrochemicals and specialty materials.
• Reference Standard: Utilized as an analytical standard for quality control and method development in pharmaceutical manufacturing.

Basic Information

Product Name	Methyl (2S,4S)-4-[2-(Trifluoromethyl)Phenoxy]-2-Pyrrolidinecarboxylate
CAS No.	1217853-18-3
Molecular Formula	C13H14F3NO3
Molecular Weight	289.25 g/mol
Synonyms	(2S,4S)-Methyl 4-(2-(trifluoromethyl)phenoxy)-2-pyrrolidinecarboxylate; Methyl 4-(2-trifluoromethylphenoxy)-L-prolinate; (2S,4S)-4-[2-(Trifluoromethyl)phenoxy]pyrrolidine-2-carboxylic acid methyl ester; L-Proline, 4-[2-(trifluoromethyl)phenoxy]-, methyl ester, (2S,4S)-; Methyl (4S)-4-[2-(trifluoromethyl)phenoxy]-L-prolinate
EINECS	Contact for details

Quality Control

Our Methyl (2S,4S)-4-[2-(Trifluoromethyl)Phenoxy]-2-Pyrrolidinecarboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting standards for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles is provided with every shipment to support your regulatory and research needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Enantiomeric Excess (Chiral HPLC)	≥99.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.