Description

(R)-(2,3-Dimethyl-3-((Trimethylsilyl)Oxy)Butyl)Diphenylphosphine Oxide is a high-value, chiral organophosphorus compound that serves as a crucial intermediate and ligand in advanced synthetic chemistry. Its primary commercial value lies in enabling highly selective catalytic transformations, particularly in the synthesis of complex pharmaceutical molecules and fine chemicals. This product is essential for R&D and production chemists in the pharmaceutical, agrochemical, and specialty chemical industries who require precise stereochemical control.

Application

• Asymmetric Catalysis: Employed as a chiral ligand or precursor for ligands in transition metal-catalyzed asymmetric hydrogenation, hydroformylation, and cross-coupling reactions.
• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs) where the introduction of a chiral phosphine oxide moiety is required for biological activity.
• Agrochemical Synthesis: Used in the development of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Material Science Research: Investigated as a component in the synthesis of novel chiral polymers or as a modifying agent for surfaces.
• Process Chemistry Development: Utilized in route scouting and optimization for the scalable production of optically active compounds.
• Academic & Industrial R&D: A valuable reagent for methodological development in organic synthesis and catalysis research.

Basic Information

Product Name	(R)-(2,3-Dimethyl-3-((Trimethylsilyl)Oxy)Butyl)Diphenylphosphine Oxide
CAS No.	1217835-38-5
Molecular Formula	C23H35O2PSi
Molecular Weight	402.59 g/mol
Synonyms	(R)-2,3-Dimethyl-3-((trimethylsilyl)oxy)butyl(diphenyl)phosphine oxide; (R)-(2,3-Dimethyl-3-(trimethylsilyloxy)butyl)diphenylphosphine oxide; (R)-Diphenyl(2,3-dimethyl-3-(trimethylsilyloxy)butyl)phosphine oxide; (R)-TMS-protected hydroxybutylphosphine oxide derivative; (R)-Chiral phosphine oxide silyl ether; (R)-DPPOTMS derivative; (R)-1-(Diphenylphosphinyl)-2,3-dimethyl-3-(trimethylsilyloxy)butane
EINECS	Contact for details

Quality Control

Our production of (R)-(2,3-Dimethyl-3-((Trimethylsilyl)Oxy)Butyl)Diphenylphosphine Oxide adheres to stringent quality protocols to ensure batch-to-batch consistency and high enantiomeric purity. Each lot is characterized using advanced analytical techniques including chiral HPLC, NMR, and GC-MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral purity, and impurity profiles is provided with every shipment, supporting compliance in cGMP and ISO 9001 environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent moisture absorption and degradation. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.