Description

(2S)-2-[3-(Trifluoromethyl)Phenyl]Pyrrolidine is a high-value chiral pyrrolidine derivative, distinguished by its trifluoromethylphenyl substituent. This compound serves as a critical chiral building block and ligand in advanced organic synthesis, particularly for the development of pharmaceuticals and agrochemicals. It is essential for research and production chemists in the pharmaceutical, agrochemical, and fine chemical industries seeking to introduce stereochemical complexity and fluorinated motifs into target molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) and metabolic disorder targets.
• Asymmetric Catalysis Ligand: Used as a precursor or direct ligand in asymmetric hydrogenation and C-C bond-forming reactions to induce high enantioselectivity.
• Agrochemical Synthesis: Employed in the synthesis of novel herbicides, fungicides, and insecticides where the trifluoromethyl group enhances biological activity and metabolic stability.
• Material Science Research: Investigated as a monomer or functional additive for creating specialty polymers with unique optical or electronic properties.
• Chemical Biology Probe: Utilized in medicinal chemistry to study enzyme inhibition and receptor-ligand interactions due to its defined stereochemistry and fluorine atoms.

Basic Information

Product Name	(2S)-2-[3-(Trifluoromethyl)Phenyl]Pyrrolidine
CAS No.	1217777-12-2
Molecular Formula	C11H12F3N
Molecular Weight	215.22 g/mol
Synonyms	(S)-2-(3-(Trifluoromethyl)phenyl)pyrrolidine; (S)-2-[3-(Trifluoromethyl)phenyl]pyrrolidine; (2S)-2-[3-(Trifluoromethyl)phenyl]pyrrolidine; (S)-3-(Trifluoromethyl)phenylpyrrolidine; (S)-α-(3-Trifluoromethylphenyl)pyrrolidine; (S)-2-(α,α,α-Trifluoro-m-tolyl)pyrrolidine; (S)-2-(3-Trifluoromethylphenyl)pyrrolidine; (S)-2-(m-Trifluoromethylphenyl)pyrrolidine
EINECS	Contact for details

Quality Control

Our (2S)-2-[3-(Trifluoromethyl)Phenyl]Pyrrolidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting standards for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere for long-term stability. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.