Description

Erythro-n-(tert-Butoxy)Carbonyl D-Homophenylalanine Epoxide is a high-purity, advanced pharmaceutical intermediate characterized by its chiral epoxide and protected amino acid structure. This compound is critical for the synthesis of complex bioactive molecules, offering precise stereochemical control for researchers and process chemists. It is primarily utilized in the development of novel active pharmaceutical ingredients (APIs) and chiral ligands within the pharmaceutical, biotechnology, and fine chemical sectors.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of protease inhibitors, enzyme modulators, and other targeted therapeutics.
• Peptidomimetic Research: Used in constructing non-natural peptide analogs and constrained scaffolds for drug discovery programs.
• Asymmetric Synthesis: Serves as a versatile electrophile in ring-opening reactions to introduce homophenylalanine derivatives with high enantiomeric purity.
• API Development: Integral in the research and process development stages for new chemical entities (NCEs), particularly in oncology and metabolic disease research.
• Chemical Biology Probes: Employed in the design and synthesis of activity-based probes and molecular tools for studying biological pathways.
• Catalyst and Ligand Preparation: A precursor for chiral ligands used in asymmetric catalysis and metal-organic frameworks.

Basic Information

Product Name	Erythro-n-(tert-Butoxy)Carbonyl D-Homophenylalanine Epoxide
CAS No.	1217728-66-9
Molecular Formula	C15H19NO5
Molecular Weight	293.32 g/mol
Synonyms	(2R,3S)-1-[(1,1-Dimethylethoxy)carbonyl]-3-phenyloxirane-2-carboxylic Acid; (2R,3S)-3-Phenylglycidic Acid N-(tert-Butoxycarbonyl); Boc-D-homoPhe(O); Erythro-N-Boc-D-homophenylalanine Epoxide; tert-Butyl (2R,3S)-3-phenyloxirane-2-carboxylate; (2R,3S)-N-Boc-3-phenyloxirane-2-carboxylic Acid; D-Homophenylalanine, N-(tert-butoxycarbonyl)-, erythro-, epoxide
EINECS	Contact for details

Quality Control

Every batch of Erythro-n-(tert-Butoxy)Carbonyl D-Homophenylalanine Epoxide is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We ensure compliance with high-purity standards suitable for research and pharmaceutical development. A detailed Certificate of Analysis (COA) providing purity, chiral purity, and impurity profile data is supplied with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and performance. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% de (erythro isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.