Description

Chloramphenicol-13C6 is a stable isotope-labeled analog of the broad-spectrum antibiotic Chloramphenicol, where six carbon atoms are replaced with the 13C isotope. This compound is an essential internal standard for the precise and accurate quantification of Chloramphenicol in complex matrices using advanced analytical techniques like LC-MS/MS. It is primarily required by analytical laboratories, contract research organizations (CROs), and pharmaceutical companies engaged in method development, pharmacokinetic studies, and regulatory compliance testing for antibiotic residues.

Application

• Internal Standard for Mass Spectrometry: Serves as a critical reference compound for the quantitative analysis of Chloramphenicol in biological fluids, food products, and environmental samples via LC-MS/MS and GC-MS.
• Pharmaceutical Research & Development: Used in pharmacokinetic and metabolism studies to track the absorption, distribution, metabolism, and excretion (ADME) of the parent drug.
• Veterinary Drug Residue Testing: Essential for ensuring food safety by detecting and quantifying Chloramphenicol residues in meat, milk, honey, and aquaculture products to comply with global maximum residue limits (MRLs).
• Clinical Toxicology: Employed in diagnostic laboratories for the precise measurement of Chloramphenicol levels in patient serum during therapeutic drug monitoring or overdose cases.
• Method Development & Validation: A key tool for developing, optimizing, and validating robust analytical methods in compliance with guidelines from FDA, EMA, and other regulatory bodies.
• Quality Control in Manufacturing: Used in the QC labs of pharmaceutical manufacturers to ensure the purity and potency of Chloramphenicol active pharmaceutical ingredients (APIs) and finished dosage forms.

Basic Information

Product Name	Chloramphenicol-13C6
CAS No.	1217706-02-9
Molecular Formula	C1113C6H12Cl2N2O5
Molecular Weight	~ 332.1 g/mol
Synonyms	Chloramphenicol (13C6); D(-)-threo-2,2-Dichloro-N-[β-hydroxy-α-(hydroxymethyl)-4-nitrophenethyl]acetamide-13C6; Chloramphenicol-13C6 (USP); Chloromycetin-13C6; 2,2-Dichloro-N-[(1R,2R)-1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl]acetamide-13C6; [13C6]-Chloramphenicol; Chloramphenicol (phenyl-13C6); Stable Isotope Labeled Chloramphenicol
EINECS	Contact for details

Quality Control

Our Chloramphenicol-13C6 is manufactured under strict quality control protocols to ensure the highest isotopic and chemical purity required for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic purity (atom % 13C), chemical purity (by HPLC), and confirmation of structure (by NMR and MS). We adhere to relevant industry standards for stable isotope-labeled compounds to guarantee reliable performance and traceability in your laboratory.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. Keep the container in a dry, well-ventilated place. For long-term storage, consider storing desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 99 atom % 13C
Chemical Purity	≥ 95% (by NMR)
Solubility	Soluble in methanol, ethanol, DMSO; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.