Description

Threo-n-(tert-Butoxy)Carbonyl L-Homophenylalanine Epoxide is a high-purity, chiral building block and advanced pharmaceutical intermediate. This compound is critically important for the synthesis of complex bioactive molecules, particularly in the development of protease inhibitors and other therapeutic agents. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in peptide-based drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of protease inhibitors and other active pharmaceutical ingredients (APIs).
• Peptide Chemistry: Used in the construction of non-natural amino acid residues and constrained peptides for drug discovery programs.
• Medicinal Chemistry Research: Serves as a versatile building block for creating compound libraries and exploring structure-activity relationships (SAR).
• Asymmetric Synthesis: Utilized in stereoselective reactions to introduce the homophenylalanine scaffold with defined stereochemistry.
• Process Development: Employed in the scale-up and optimization of synthetic routes for candidate drugs.

Basic Information

Product Name	Threo-n-(tert-Butoxy)Carbonyl L-Homophenylalanine Epoxide
CAS No.	1217636-74-2
Molecular Formula	C15H19NO5
Molecular Weight	293.32 g/mol
Synonyms	(2S,3S)-1-[(tert-Butoxy)carbonyl]-3-phenyloxirane-2-carboxylic Acid; (2S,3S)-1-(Boc)-3-phenyloxirane-2-carboxylic Acid; (2S,3S)-3-Phenylglycidic Acid N-Boc Derivative; Boc-L-homoPhe(2,3-epoxide); Threo-Boc-Homophenylalanine Epoxide; (2S,3S)-1-((tert-Butoxycarbonyl)amino)-2,3-epoxy-4-phenylbutan-2-one (tautomeric form); L-Homophenylalanine, N-Boc-2,3-epoxide, threo- isomer
EINECS	Contact for details

Quality Control

Our Threo-n-(tert-Butoxy)Carbonyl L-Homophenylalanine Epoxide is manufactured under strict quality management systems. Each batch is subjected to rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical and enantiomeric purity suitable for pharmaceutical research. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.