Description

2-Butoxy-5-Chloropyridin-3-Ylboronic Acid is a specialized organoboron compound, specifically a pyridine-based boronic acid derivative, serving as a crucial building block in modern synthetic chemistry. Its core value lies in its role as a versatile coupling partner in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl and heterobiaryl structures. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly in the development of active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for compounds containing complex pyridine scaffolds.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides that require specific chloropyridine motifs.
• Material Science Research: Serves as a building block for organic electronic materials, such as ligands for catalysts and components for organic light-emitting diodes (OLEDs).
• Suzuki-Miyaura Cross-Coupling: Primary application as a boronic acid coupling partner with aryl/heteroaryl halides to form carbon-carbon bonds under palladium catalysis.
• Chemical Biology & Proteomics: Potential use in developing molecular probes and inhibitors that target specific biological pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for bespoke synthesis projects.

Basic Information

Product Name	2-Butoxy-5-Chloropyridin-3-Ylboronic Acid
CAS No.	1217501-44-4
Molecular Formula	C9H13BClNO3
Molecular Weight	229.47 g/mol
Synonyms	(2-Butoxy-5-chloropyridin-3-yl)boronic acid; 5-Chloro-2-butoxy-3-pyridineboronic acid; 3-Borono-5-chloro-2-butoxypyridine; 2-n-Butoxy-5-chloro-3-pyridineboronic acid; Boronic acid, B-(2-butoxy-5-chloro-3-pyridinyl)-; 5-Chloro-2-butoxypyridine-3-boronic acid; 1217501-44-4; Contact for EINECS details.

Quality Control

Our 2-Butoxy-5-Chloropyridin-3-Ylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and batch-to-batch consistency. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment. We adhere to industry best practices, and specifications can be tailored to meet specific project requirements, including those for cGMP (current Good Manufacturing Practice) applications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated place. This material is hygroscopic (moisture-sensitive) and easily oxidized; therefore, containers must be kept sealed and handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.