Description

6-Chloro-4-(Trifluoromethyl)Pyridine-2-Boronic Acid is a high-value, multi-functional boronic acid derivative essential for modern synthetic chemistry. This compound serves as a critical building block in cross-coupling reactions, enabling the efficient construction of complex molecular architectures. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly in kinase inhibitor and antiviral research.
• Agrochemical Synthesis: Used to construct pyridine-based active ingredients for crop protection products, leveraging the stability of the trifluoromethyl and chloro substituents.
• Material Science Research: Employed in the development of organic electronic materials, such as ligands for metal-organic frameworks (MOFs) or components for organic light-emitting diodes (OLEDs).
• Chemical Biology Probes: Acts as a versatile handle for bioconjugation and the creation of chemical probes to study biological pathways and protein function.
• Catalyst Ligand Development: Serves as a starting material for synthesizing novel bidentate or tridentate ligands used in homogeneous catalysis.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring specific, functionalized pyridine cores.

Basic Information

Product Name	6-Chloro-4-(Trifluoromethyl)Pyridine-2-Boronic Acid
CAS No.	1217500-88-3
Molecular Formula	C6H4BClF3NO2
Molecular Weight	225.36 g/mol
Synonyms	2-Borono-6-chloro-4-(trifluoromethyl)pyridine; [6-Chloro-4-(trifluoromethyl)-2-pyridinyl]boronic acid; 6-Chloro-4-trifluoromethylpyridine-2-boronic acid; 6-Chloro-4-(trifluoromethyl)-2-pyridineboronic acid; 2-Pyridineboronic acid, 6-chloro-4-(trifluoromethyl)-; (6-Chloro-4-(trifluoromethyl)pyridin-2-yl)boronic acid
EINECS	Contact for details

Quality Control

Our 6-Chloro-4-(Trifluoromethyl)Pyridine-2-Boronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or when opening a new container to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.