Description

(R)-α,α-Bis(3,5-Dimethylphenyl)-2-Pyrrolidinemethanol Trimethylsilyl Ether Hydrochloride 97% is a high-purity chiral intermediate of significant importance in advanced organic synthesis. This compound matters for its role as a key building block in the development of enantiomerically pure pharmaceuticals and fine chemicals, where stereochemical control is critical. It is primarily needed by research and development laboratories, process chemists, and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the research and production of active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and receptor-targeting drugs.
• Asymmetric Catalysis Research: Used as a precursor or ligand in the development of novel asymmetric catalytic systems for enantioselective synthesis.
• Agrochemical Synthesis: Serves as a building block for creating enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Material Science: Potential monomer or additive in the synthesis of specialty polymers with specific optical or chiral properties.
• Academic & Industrial R&D: Employed in method development and scale-up studies for complex organic transformations requiring high stereochemical fidelity.
• Reference Standard: Used as a high-purity analytical standard for quality control and method validation in chromatographic analysis.

Basic Information

Product Name	(R)-α,α-Bis(3,5-Dimethylphenyl)-2-Pyrrolidinemethanol Trimethylsilyl Ether Hydrochloride 97%
CAS No.	1217450-13-9
Molecular Formula	C25H37NO2Si • HCl
Molecular Weight	440.12 g/mol (Free base: 403.66 g/mol)
Synonyms	(R)-α,α-Bis(3,5-dimethylphenyl)-2-pyrrolidinemethanol trimethylsilyl ether hydrochloride; (R)-TMS-Prolinol Derivative Hydrochloride; (R)-2-[(Trimethylsilyl)oxy]methyl-α,α-bis(3,5-dimethylphenyl)pyrrolidine hydrochloride; (R)-α,α-Bis(3,5-xylyl)-2-pyrrolidinemethanol TMS ether HCl; (R)-TMS-Protected Prolinol Benzyl Ether Hydrochloride; (R)-1-(3,5-Dimethylphenyl)-1-(3,5-dimethylphenyl)(pyrrolidin-2-yl)methanol trimethylsilyl ether hydrochloride
EINECS	Contact for details

Quality Control

Our (R)-α,α-Bis(3,5-Dimethylphenyl)-2-Pyrrolidinemethanol Trimethylsilyl Ether Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure identity, purity, and enantiomeric excess meet the specified 97% minimum standard. Certificates of Analysis (COA) with full analytical data are provided to guarantee traceability and batch-to-batch consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.