Description

(R)-2-{Bis[3,5-Bis(Trifluoromethyl)Phenyl]Methoxy-Methyl}Pyrrolidine Hydrochloride is a high-purity chiral building block and organocatalyst of significant interest in advanced synthetic chemistry. Its value lies in its unique structure, featuring multiple trifluoromethyl groups that impart desirable properties like enhanced lipophilicity and metabolic stability to target molecules. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries developing novel active ingredients, particularly where stereochemical control is critical.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, especially for central nervous system (CNS) and antiviral therapies.
• Asymmetric Organocatalysis: Serves as a precursor or structural motif for developing novel chiral catalysts used in enantioselective synthesis.
• Agrochemical Synthesis: Employed in creating advanced, stereochemically defined active ingredients for crop protection products.
• Ligand for Metal Complexes: Used in the preparation of specialized ligands for catalytic systems in fine chemical manufacturing.
• Material Science Research: Investigated as a building block for specialty polymers and advanced organic materials with unique fluorinated properties.
• Academic & Process R&D: A valuable tool for methodological studies in organic synthesis and scale-up process optimization in contract research organizations (CROs) and CDMOs.

Basic Information

Product Name	(R)-2-{Bis[3,5-Bis(Trifluoromethyl)Phenyl]Methoxy-Methyl}Pyrrolidine Hydrochloride
CAS No.	1217447-55-6
Molecular Formula	C22H19F12NO2 • HCl
Molecular Weight	593.84 g/mol (Free base: 557.38 g/mol)
Synonyms	(R)-2-((Bis(3,5-bis(trifluoromethyl)phenyl)methoxy)methyl)pyrrolidine hydrochloride; (R)-2-({Bis[3,5-bis(trifluoromethyl)phenyl]methoxy}methyl)pyrrolidine HCl; (R)-DTBM-Pyrrolidine Hydrochloride; (R)-Jørgensen-Hayashi Catalyst Derivative Hydrochloride; (R)-α,α-Bis[3,5-bis(trifluoromethyl)phenyl]-2-pyrrolidinemethanol Methyl Ether Hydrochloride; (R)-2-[(Bis(3,5-di(trifluoromethyl)phenyl)methoxy)methyl]pyrrolidine hydrochloride
EINECS	Contact for details

Quality Control

Our (R)-2-{Bis[3,5-Bis(Trifluoromethyl)Phenyl]Methoxy-Methyl}Pyrrolidine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for chiral purity and chemical assay, NMR for structural confirmation, and KF titration for water content. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC, Area %)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.