Description

1-[5-Bromo-2-(Difluoromethoxy)Phenyl]Ethan-1-One is a high-purity, advanced pharmaceutical intermediate characterized by its bromo-difluoromethoxy substituted aromatic ketone structure. This compound is a critical building block in modern synthetic organic chemistry, enabling the development of novel active pharmaceutical ingredients (APIs) with enhanced properties. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the synthesis of complex molecules targeting a range of therapeutic and crop protection applications.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in medicinal chemistry research for central nervous system (CNS) and anti-inflammatory targets.
• Agrochemical Synthesis: Serves as a versatile building block for developing advanced herbicides and pesticides, leveraging the bioactivity of the difluoromethoxy and bromo substituents.
• Material Science Research: Used in the development of specialty polymers and liquid crystals, where its aromatic core and halogenated groups can influence material properties.
• Organic Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and other transformations to construct complex molecular architectures in academic and industrial R&D.
• Fluorinated Compound Library Development: Essential for creating libraries of fluorinated compounds in drug discovery programs to optimize metabolic stability and binding affinity.

Basic Information

Product Name	1-[5-Bromo-2-(Difluoromethoxy)Phenyl]Ethan-1-One
CAS No.	1215994-75-4
Molecular Formula	C9H7BrF2O2
Molecular Weight	265.05 g/mol
Synonyms	5'-Bromo-2'-(difluoromethoxy)acetophenone; 1-(5-Bromo-2-(difluoromethoxy)phenyl)ethanone; 2'-Difluoromethoxy-5'-bromoacetophenone; Ethanone, 1-[5-bromo-2-(difluoromethoxy)phenyl]-; 5-Bromo-2-(difluoromethoxy)acetophenone; 1-Acetyl-5-bromo-2-(difluoromethoxy)benzene; 2-(Difluoromethoxy)-5-bromoacetophenone
EINECS	Contact for details

Quality Control

Our 1-[5-Bromo-2-(Difluoromethoxy)Phenyl]Ethan-1-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency suitable for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container must be kept tightly sealed due to potential moisture sensitivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.