Description

3-Fluoro-4-(Trifluoromethyl)-Dl-Phenylalanine is a non-natural, fluorinated amino acid derivative of significant interest in advanced chemical synthesis. This compound matters for its role as a critical building block in medicinal chemistry, where its unique fluorine substitution pattern can dramatically alter the metabolic stability, lipophilicity, and binding affinity of target molecules. Pharmaceutical researchers and fine chemical manufacturers need it for developing novel active pharmaceutical ingredients (APIs), peptide mimetics, and as a precursor for complex molecular libraries.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new therapeutic agents, particularly in oncology and CNS disorders.
• Peptidomimetics & PROTACs: Used to incorporate fluorinated motifs into peptide backbones and linker structures for targeted protein degradation technologies.
• Agrochemical Research: Serves as a precursor in the synthesis of novel herbicides and pesticides with enhanced environmental stability.
• Fluorine Chemistry & Material Science: Acts as a valuable scaffold for creating fluorinated liquid crystals, polymers, and specialty materials with unique surface properties.
• Biochemical Tool Development: Employed in the design of enzyme inhibitors, receptor ligands, and fluorescent probes for biological assays.
• Academic & Contract Research: Essential for universities and CROs conducting fundamental research in synthetic organic chemistry and drug discovery.

Basic Information

Product Name	3-Fluoro-4-(Trifluoromethyl)-Dl-Phenylalanine
CAS No.	1215491-31-8
Molecular Formula	C10H9F4NO2
Molecular Weight	251.18 g/mol
Synonyms	DL-3-Fluoro-4-(trifluoromethyl)phenylalanine; (±)-2-Amino-3-[3-fluoro-4-(trifluoromethyl)phenyl]propanoic acid; 3-Fluoro-4-trifluoromethyl-DL-phenylalanine; 3-Fluoro-4-(trifluoromethyl)phenylalanine, DL-; F4-Phe; 4-(Trifluoromethyl)-3-fluorophenylalanine; (RS)-3-Fluoro-4-(trifluoromethyl)phenylalanine
EINECS	Contact for details

Quality Control

Our 3-Fluoro-4-(Trifluoromethyl)-Dl-Phenylalanine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and MS, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Assay	97.0% - 102.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.