Description

1 - Fluoro - 3 - Hydroxycyclobutanecarbonitrile is a high-value, multifunctional cyclobutane derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring both a fluorine atom and a nitrile group on a strained four-membered ring, makes it an indispensable intermediate for constructing complex molecular architectures. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of fluorinated drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, anti-infectives, and oncology.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides where the fluorine atom and cyclobutane ring can enhance biological activity and environmental stability.
• Ligand & Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts, leveraging the stereogenic centers of the cyclobutane ring for asymmetric synthesis.
• Material Science Monomer: Potential use in polymer chemistry for creating specialty polymers with unique thermal and chemical resistance properties.
• Fluorine Chemistry Building Block: Employed in exploratory synthetic chemistry to introduce the cyclobutane scaffold and a reactive nitrile handle into target molecules.

Basic Information

Product Name	1 - Fluoro - 3 - Hydroxycyclobutanecarbonitrile
CAS No.	1215071-22-9
Molecular Formula	C5H6FNO
Molecular Weight	115.10 g/mol
Synonyms	3-Fluoro-1-hydroxycyclobutanecarbonitrile; 1-Fluoro-3-hydroxycyclobutanecarbonitrile; 3-Hydroxy-1-fluorocyclobutanecarbonitrile; (3-Fluorocyclobutyl)(hydroxy)acetonitrile; 1-Fluoro-3-hydroxy-cyclobutanecarbonitrile; 1-Fluoro-3-hydroxycyclobutanenitrile; 3-Fluoro-1-hydroxycyclobutanenitrile
EINECS	Contact for details

Quality Control

Our 1 - Fluoro - 3 - Hydroxycyclobutanecarbonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications. For custom synthesis or specific purity grades (e.g., >98%, >99%), please contact our technical sales team.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and potential degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.