Description

4-Bromo-2-(Trifluoromethyl)Benzoic Acid Ethyl Ester is a high-value fluorinated aromatic building block. This compound matters for its unique combination of bromo and trifluoromethyl substituents, which are critical for modulating the lipophilicity, metabolic stability, and binding affinity of target molecules. It is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for synthesizing novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors, anti-inflammatory agents, and CNS-active compounds.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, where the trifluoromethyl group enhances biological activity and environmental persistence.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for fluorinated aromatic cores used in electronic display technologies and organic light-emitting diodes (OLEDs).
• Cross-Coupling Reactions: The bromo substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira) to create complex biaryl structures.
• Chemical Research & Development: Employed in academic and industrial R&D labs for exploring new synthetic methodologies and creating specialized chemical libraries.
• Fluorine Chemistry Studies: Acts as a model compound for studying the electronic effects and reactivity of polyfluorinated aromatic systems.

Basic Information

Product Name	4-Bromo-2-(Trifluoromethyl)Benzoic Acid Ethyl Ester
CAS No.	1214378-94-5
Molecular Formula	C10H8BrF3O2
Molecular Weight	297.07 g/mol
Synonyms	Ethyl 4-Bromo-2-(trifluoromethyl)benzoate; Benzoic acid, 4-bromo-2-(trifluoromethyl)-, ethyl ester; 4-Bromo-α,α,α-trifluoro-o-toluic acid ethyl ester; Ethyl 4-bromo-α,α,α-trifluoro-o-toluate; 2-Trifluoromethyl-4-bromobenzoic acid ethyl ester; 4-Bromo-2-trifluoromethylbenzoic acid ethyl ester; 1214378-94-5; Ethyl 4-bromo-2-(trifluoromethyl)benzoate
EINECS	Contact for details

Quality Control

Our 4-Bromo-2-(Trifluoromethyl)Benzoic Acid Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support cGMP compliance for pharmaceutical applications and can tailor purity grades to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong acids and organic solvents. The container must be kept tightly closed in a dry and well-ventilated place.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0% (Standard Grade)
Purity (GC)	≥97.5%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.