Description

Ethyl 2,5-Difluoro-4-Nitrobenzoate is a high-purity fluorinated aromatic ester derivative, serving as a critical advanced intermediate in modern synthetic chemistry. Its value lies in providing a versatile, functionalized scaffold for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and agrochemicals. This compound is essential for research and production facilities in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce fluorine and nitro functional groups into target structures.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders, anti-infectives, and oncology therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, where the fluorine atoms enhance biological activity and environmental stability.
• Material Science Research: Serves as a precursor for developing specialty polymers, liquid crystals, and organic electronic materials requiring fluorinated aromatic units.
• Chemical Biology & Proteomics: Employed as a reagent for synthesizing fluorinated probes, tags, and linkers used in bio-conjugation and imaging studies.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects and contract research organizations (CROs/CMOs) developing proprietary compounds.

Basic Information

Product Name	Ethyl 2,5-Difluoro-4-Nitrobenzoate
CAS No.	1214367-00-6
Molecular Formula	C9H7F2NO4
Molecular Weight	231.15 g/mol
Synonyms	Benzoic acid, 2,5-difluoro-4-nitro-, ethyl ester; Ethyl 2,5-difluoro-4-nitrobenzoate; 4-Nitro-2,5-difluorobenzoic acid ethyl ester; 2,5-Difluoro-4-nitrobenzoic acid ethyl ester; Ethyl 4-nitro-2,5-difluorobenzoate; EFNB; CAS 1214367-00-6
EINECS	Contact for details

Quality Control

Our Ethyl 2,5-Difluoro-4-Nitrobenzoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment aligns with cGMP principles where applicable, supporting our customers' regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This compound is light-sensitive and easily oxidized; for long-term storage, consider maintaining under an inert atmosphere (e.g., nitrogen or argon) to preserve stability and prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0% (Area Percent)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.