Description

Ethyl 3-Chloro-5-(Trifluoromethyl)Benzoate is a high-value fluorinated aromatic ester building block, essential for advanced chemical synthesis. Its core value lies in the strategic combination of chlorine and trifluoromethyl substituents, which impart unique electronic and steric properties to target molecules. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring fluorinated motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group is a critical pharmacophore for activity.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing fluorinated aromatic cores used in electronic display technologies and organic light-emitting diodes.
• Advanced Polymer Modification: Employed to introduce fluorine-containing side chains into polymers, altering their surface properties, chemical resistance, and dielectric characteristics.
• Custom Synthesis & Contract Manufacturing: A vital reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences market.
• Research & Development: Fundamental scaffold in medicinal chemistry and material science research for structure-activity relationship (SAR) studies and novel compound library generation.

Basic Information

Product Name	Ethyl 3-Chloro-5-(Trifluoromethyl)Benzoate
CAS No.	1214366-88-7
Molecular Formula	C10H8ClF3O2
Molecular Weight	252.62 g/mol
Synonyms	Benzoic acid, 3-chloro-5-(trifluoromethyl)-, ethyl ester; Ethyl 3-chloro-α,α,α-trifluoro-m-toluate; 3-Chloro-5-(trifluoromethyl)benzoic acid ethyl ester; m-Chloro-α,α,α-trifluoromethylbenzoic acid ethyl ester; Ethyl 3-chloro-5-trifluoromethylbenzoate; Ethyl 3-chloro-5-(trifluoromethyl)benzoate
EINECS	Contact for details

Quality Control

Our Ethyl 3-Chloro-5-(Trifluoromethyl)Benzoate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.